Antischizophrenic drugs: chronic treatment elevates dopamine receptor binding in brain.
نویسندگان
چکیده
Chronic treatment of rats with the neuroleptic drugs haloperidol, fluphenazine, and reserpine elicits a 20 to 25% increase in striatal dopamine receptor binding assayed with [3H]haloperidol. This increase in receptor sites may account for behavioral supersensitivity to dopamine receptor stimulants in such animals and for tardive dyskinesia in patients treated with these drugs.
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عنوان ژورنال:
- Science
دوره 196 4287 شماره
صفحات -
تاریخ انتشار 1977